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In vitro antitumour activity of flavonoids from Sophora flavescens

โœ Scribed by Shi Yong Ryu; Sang Un Choi; Seong-Kie Kim; Zaesung No; Chong Ock Lee; Jong Woong Ahn; Sung Hoon Kim

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
90 KB
Volume
11
Category
Article
ISSN
0951-418X

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โœฆ Synopsis

The cytotoxicity-guided fractionation of the roots of Sophora flavescens (Leguminosae) extracts led to the isolation of 15 active principles 1-15, responsible for cytotoxicity against five kinds of cultured human tumour cell lines, i.e. A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (skin), XF498 (central nerve system) and HCT-15 (colon), evaluated by SRB method in vitro. Compounds 2-14 were classified as unusual flavonoids occurring exclusively in this species and the proliferation of each of the examined tumour cells were significantly inhibited during continuous exposure to compounds 1-15 for 48 h, respectively.

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