✦ LIBER ✦

The in vitro Antitumour Activity of Substituted Dibutyl-1,3,2-dioxastannolanes

✍ Scribed by S. C. Ng; Peter G. Parsons; K. Y. Sim; Carolyn J. Tranter; Rodney H. White; David J. Young

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 128 KB
Volume: 11
Category: Article
ISSN: 0268-2605
DOI: 10.1002/(sici)1099-0739(199707)11:7<577::aid-aoc612>3.0.co;2-s

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✦ Synopsis

Six dibutyl-1,3,2-dioxastannolanes, including two enantiomeric pairs, exhibited greater in vitro antitumour activity towards a variety of human tumour cell lines than cisplatin but with little discrimination, suggesting hydrolysis to a common cytotoxic intermediate. A cell line hypersensitive to mitochondrial inhibitors (CI80-13S) was not sensitive to any of the test compounds, suggesting that cell mechanisms other than, or in addition to, mitochondrial function are targeted by tin antitumour agents. A pigmented melanoma cell line (MM418c5) was resistant to the test compounds, which were found to be sequestered by melanin. This resistance was not observed with triphenyltin hydroxide.

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