Gastrin/CCK B G protein-coupled receptors have been shown to mediate proliferation stimulated by their endogenous ligands. The present study demonstrates the proliferative effect of arachidonic acid on AR4-2J cells. Gastrin induces an [ 3 H]arachidonic-acid release in a dose-dependent manner. The us
Cytosolic phospholipase A2and lipoxygenase are involved in cell cycle progression in neuroblastoma cells
β Scribed by G.S.A.T. van Rossum; J.J.M. Bijvelt; H. van den Bosch; A.J. Verkleij; J. Boonstra
- Book ID
- 105757439
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 303 KB
- Volume
- 59
- Category
- Article
- ISSN
- 1420-682X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The present study underlines the importance of phospholipase A~2~ (PLA~2~)β and lipoxygenase (LO)βmediated signaling processes in the regulation of inducible nitric oxide synthase (iNOS) gene expression. In glial cells, lipopolysaccharide (LPS) induced the activities of PLA~2~ (calciumβ
A candidate murine tumor-suppressor gene, Mom1, has been identified as the secretory phospholipase A2 (GDB nomenclature: PLA2G2A) gene. Evidence suggests that PLA2G2A functions as a tumor-suppressor because mice lacking PLA2G2A expression demonstrate increased colonic polyposis. The human homologue