Growth Inhibition and Death Induction in Tumor Cells by Inhibitors of Phospholipase A2 and Lipoxygenase
β Scribed by V. V. Shaposhnikova; L. N. Kublik; A. A. Narimanov; M. Kh. Levitman; O. E. Orlova; A. A. Kudryavtsev; V. V. Leshchenko; Yu. N. Korystov
- Book ID
- 110273940
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 44 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1062-3590
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## Abstract Secretory phospholipase A~2~ (sPLA~2~βIIA) has been shown to attenuate intestinal tumorigenesis in __Apc^Min^__ mice, demonstrating that it is a tumor modifier. To further explore the actions of sPLA~2~βIIA in tumorigenesis, sPLA~2~βIIA was overexpressed in two cell lines where it is no
The effects of a new metalloproteinase inhibitor, BE 16627B [L-N-(N-hydroxy-2-isobutylsuccinynamoyl)-se~l-L-valine, M W 375.21 isolated from microbial cultures, on human tumor cell growth in nude mice were investigated. BEl6627B inhibited metalloproteinases in enzyme assays, as well as gelatinolysis