𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Arachidonic-acid-selective cytosolic phospholipase A2 is involved in gastrin-induced AR4-2J-cell proliferation

✍ Scribed by Farida Ghrib; Stéphane Pyronnet; Marie-José Bastié; Pierrette Fagot-Revurat; Lucien Pradayrol; Nicole Vaysse

Publisher
John Wiley and Sons
Year
1998
Tongue
French
Weight
126 KB
Volume
75
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Gastrin/CCK B G protein-coupled receptors have been shown to mediate proliferation stimulated by their endogenous ligands. The present study demonstrates the proliferative effect of arachidonic acid on AR4-2J cells. Gastrin induces an [ 3 H]arachidonic-acid release in a dose-dependent manner. The use of a specific inhibitor of cPLA2, AACOCF3 established the involvement of a cPLA2 in the proliferative effect of gastrin. The results also demonstrate that a cytosolic highmolecular-weight PLA2 is activated by gastrin in AR4-2J cells.

📜 SIMILAR VOLUMES

Calcium-independent phospholipase A2 thr
Calcium-independent phospholipase A2 through arachidonic acid mobilization is involved in Caco-2 cell growth
✍ Teresa Sanchez; Juan J. Moreno 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 123 KB

## Abstract Several studies indicate that phospholipase A~2~ (PLA~2~) expression and/or activation account for the high levels of arachidonic acid (AA) detected in cancer and, together with the elevated expression of cyclooxygenase‐2, lead to cell proliferation and tumor formation. Using Caco‐2 cel