๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Cytokines that regulate autoimmune responses

โœ Scribed by Marika Falcone; Nora Sarvetnick

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
92 KB
Volume
11
Category
Article
ISSN
0952-7915

No coin nor oath required. For personal study only.

โœฆ Synopsis

Autoimmune responses are controlled by complex regulatory circuits. Previous work has revealed that factors controlling autoimmunity can act both as potentiating and inhibitory agents, depending upon the site and timing of exposure. Recent advances in this complex field have at least partially uncovered the mechanism whereby these regulatory molecules participate in autoimmune processes. IL-12 production in the absence of infection may predispose to autoimmunity. IL-4 and transforming growth factor ฮฒ may suppress autoreactive T cells. Proinflammatory cytokines may ameliorate autoimmunity, dependent on the timing and level of production. In many cases, cytokines may act via antigen-presenting cells.

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