✦ LIBER ✦

Regulation and biological function of helminth-induced cytokine responses

✍ Scribed by Fred D. Finkelman; Edward J. Pearce; Joseph F. Urban Jr; Alan Sher

Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 613 KB
Volume: 12
Category: Article
ISSN: 0167-5699
DOI: 10.1016/s0167-5699(05)80018-0

No coin nor oath required. For personal study only.

✦ Synopsis

The immunological hallmarks of infection with parasitic helminths, namely eosinophilia, mastocytosis and increased IgE synthesis, all appear to be induced by cytokines from the TH2 subset of CD4+ T cells: IgE production is stimulated by interleukin 4 (IL-4), eosinophilia by IL-5 and mastocytosis by IL-3 and IL-4. Here, Fred Finkelman and colleagues argue that the functional significance of the eosinophilia-mastocytosis-IgE axis in helminth infection is unclear and suggest that in some worm infections TH2-cell cytokines may contribute to host protection, while in others they may promote parasite survival.

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