๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Role of cytokines in lipopolysaccharide-induced functional and structural abnormalities of astrocytes

โœ Scribed by Shuxian Hu; Alice Martella; W. Robert Anderson; Dr. Chun C. Chao

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
904 KB
Volume
10
Category
Article
ISSN
0894-1491

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โœฆ Synopsis

The mechanism underlying meningitis-associated brain injury is unclear. This study investigated the hypothesis that lipopolysaccharide (LPS) alters astrocyte function and structure via the release of proinflammatory cytokines. In enriched murine astrocyte cultures, LPS inhibited (P < 0.05) glutamine synthetase activity, 3Hgamma aminobutyric acid uptake, and DNA synthesis; LPS also induced ultrastructural changes. Antibodies to tumor necrosis factor-a, interleukin-1, and interleukin-6 blocked ( P < 0.05) in part the LPS-induced inhibition of astrocyte function. Also, treatment of astrocyte cultures with cytokines significantly altered these astrocyte functions and ultrastructure. Taken together, the present findings support the hypothesis that LPS affects astrocyte function and structure via the release of proinflammatory cytokines, especially tumor necrosis factor-a.

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