Autoimmune responses are controlled by complex regulatory circuits. Previous work has revealed that factors controlling autoimmunity can act both as potentiating and inhibitory agents, depending upon the site and timing of exposure. Recent advances in this complex field have at least partially uncov
Cytokine-regulated proteases in autoimmune diseases
โ Scribed by Ghislain Opdenakker; Jo Van Damme
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 625 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0167-5699
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Studies extending over a decade have provided compelling evidence to suggest that chronic expression of proinflammatory cytokines in vivo leads to unique regulatory properties that target the cognate immune response in a way that appears to be beneficial to the host. This review focuses on the proto
Multiple lines of evidence implicate cytokines in the pathogenesis of autoimmune and inflammatory diseases. Neutralization of the biological activities of cytokines by interfering with ligand binding to specific cell-surface cytokine receptors thus represents an approach to controlling such diseases
We previously reported that recovery of Lewis rats from experimental autoimmune encephalomyelitis (EAE) is associated with the appearance of suppressor T cells (Ts). These Ts secrete TGF-beta which down-regulates the production of inflammatory cytokines by the effector T cells that mediate this dise