✦ LIBER ✦

Cytokine regulation of secondary lymphoid organ development

✍ Scribed by David D Chaplin; Yang-xin Fu

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 902 KB
Volume: 10
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(98)80167-2

No coin nor oath required. For personal study only.

✦ Synopsis

Lymphotoxin and tumor necrosis factor provide essential signals for the formation of secondary lymphoid tissue structures. Lymphotoxin in its membrane form (LT alpha 1 beta 2 heterotrimer) is required for the development of lymph nodes and Peyer's patches and supports the development of normal spleen structure. In the spleen, lymphotoxin acts during embryonic development to support the formation of distinct B and T cell zones. Lymphotoxin also acts in a tonic fashion-supporting the formation and maintenance of the follicular dendritic cell network and of primary B cell follicle structure. The cells that deliver the tonic lymphotoxin signal supporting follicular dendritic cell structure are B cells; thus, B cells participate fundamentally in the development of the lymphoid tissue structure in which they subsequently mature.

📜 SIMILAR VOLUMES

Elucidating the functional anatomy of se

Elucidating the functional anatomy of secondary lymphoid organs

✍ Oliver Pabst; Heike Herbrand; Günter Bernhardt; Reinhold Förster 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 381 KB

Functional anatomy offers an attempt to exploit anatomical information as a platform from which to decipher mechanistic details of complex or multistep immunological processes. Immune function depends on structural organization, therefore this approach contributes to a comprehensive understanding of

Lymphoid organ development in Xenopus th

Lymphoid organ development in Xenopus thymectomized at eight days of age

✍ John D. Horton; Margaret J. Manning 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 English ⚖ 763 KB

## Abstract This paper examines the effect of early thymectomy on the subsequent development of lymphoid tissues in the toad, __Xenopus laevis__. At the time of thymic removal (8 days post‐fertilization) all the lymphoid organ anlagen are at a rudimentary state of differentiation and contain few, i

Secondary lymphoid organs are dispensabl

Secondary lymphoid organs are dispensable for the development of T-cell-mediated immunity during tuberculosis

✍ Tracey A. Day; Markus Koch; Geraldine Nouailles; Marc Jacobsen; George A. Kosmia 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 677 KB

## Abstract Tuberculosis causes 2 million deaths __per__ year, yet in most cases the immune response successfully contains the infection and prevents disease outbreak. Induced lymphoid structures associated with pulmonary granuloma are observed during tuberculosis in both humans and mice and could

Involvement of the Fas (CD95) system in

Involvement of the Fas (CD95) system in peripheral cell death and lymphoid organ development

✍ Yasmina Laouar; Adelaida Sarukhan; Valérie Pasqualetto; Corinne Garcia; Sophie E 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 240 KB 👁 2 views

Fas-mediated apoptosis is a form of cell death that operates through a Fas-Fas ligand (FasL) interaction. In this study we investigated the role of the Fas system during development of normal and Fas-mutated lymphocytes. Irradiated RAG2 -/-recipients were reconstituted with bone marrow cells from B6

Development of specific antibody-forming

Development of specific antibody-forming cells in various lymphoid organs of rabbit after intravenous antigen administration

✍ van der Brugge-Gamelkoorn, Gerda J. ;Kors, Nel ;van Rooijen, Nico 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 558 KB

Immunodeficiency of alymphoplasia mice (

Immunodeficiency of alymphoplasia mice (aly/aly) in vivo: structural defect of secondary lymphoid organs and functional B cell defect

✍ Urs Karrer; Alana Althage; Bernhart Odermatt; Hans Hengartner; Rolf M. Zinkernag 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 369 KB 👁 2 views