Lymphoid organ development in Xenopus thymectomized at eight days of age

✍ Scribed by John D. Horton; Margaret J. Manning

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 763 KB
• Volume: 143
• Category: Article
• ISSN: 0362-2525
• DOI: 10.1002/jmor.1051430403

✦ Synopsis

Abstract

This paper examines the effect of early thymectomy on the subsequent development of lymphoid tissues in the toad, Xenopus laevis. At the time of thymic removal (8 days post‐fertilization) all the lymphoid organ anlagen are at a rudimentary state of differentiation and contain few, if any, small lymphocytes. Despite the absence of any thymic tissue all thymectomized animals grew normally.

Thymectomized larvae developed relatively normal lymphoid organs. However, lymphoid depletion was apparent in the splenic red pulp and in the pharyngeal ventral cavity bodies. Examination of the lymphoid organs of post‐metamorphic Xenopus revealed reduction in spleen size following thymectomy. Lymphoid depletion was evident in the splenic red pulp of many thymectomized toadlets and reduction in proportion of white to red pulp was also noted in a few of these animals. Absence of the thymus had no apparent effect on the histology of the other lymphoid organs examined.