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Cytogenetics of a malignant ovarian germ-cell tumor

✍ Scribed by Jannie van Echten; Lena C. van Doorn; Hans C. van der Linden; Anneke Y. van der Veen; Curt W. Burger; Bauke de Jong

Publisher: John Wiley and Sons
Year: 1998
Tongue: French
Weight: 98 KB
Volume: 77
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19980717)77:2<217::aid-ijc8>3.0.co;2-t

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✦ Synopsis

Cytogenetic investigation of a malignant ovarian tumor diagnosed as a mixed germ-cell tumor, composed of extensive choriocarcinoma and foci of yolk-sac tumor, revealed a highly abnormal chromosomal pattern. We found a chromosome number in the hypertriploid/hypotetraploid range, and several clonal structural abnormalities, including 2 copies of an isochromosome 12p. We showed that the chromosomal pattern of this ovarian tumor is very similar to that of testicular germ-cell tumors. This finding, together with reported cytogenetic data of malignant ovarian germ-cell tumors, supports the hypothesis that ovarian and testicular germ-cell tumors are strongly related entities that may have a similar origin and pathogenetic pathway. Int.

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