𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cytogenetic studies on 19 papillary thyroid carcinomas

✍ Scribed by Patrick Antonini; Anne-Marie Venuat; Bernard Caillou; Roland Berger; Martin Schlumberger; Alain Bernheim; Claude Parmentier


Book ID
102845424
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
528 KB
Volume
5
Category
Article
ISSN
1045-2257

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✦ Synopsis


Short-term cultures from I9 papillary thyroid adenocarcinomas revealed clonal numerical and/or structural chromosomal changes in I3 tumors, nonclonal abnormalities in one tumor, and only normal karyotypes in five tumors. Clonal abnormalities of chromosome 10 were present in three tumors, two of which had the translocation t(7; IO)(q35;q2 I). Numerical abnormalities of chromosome I 7 were detected in two tumors. Genes Chrom Cancer 5:206-2 I / ( / 992). @ 1992 Wiley-Lirs. Inc.


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A combined cytogenetic and molecular analysis was performed on I I cases of papillary thyroid carcinoma. A simple karyotypic abnormality was detected in five tumors, whereas six had no apparent chromosome change. In four of five rearranged cases the presence of a specific chromosomal abnormality inv