Cytogenetic and molecular genetic characterization of papillary thyroid carcinomas

✍ Scribed by Dr. Gabrielia Sozzi; Italia Bongarzone; Monica Miozzo; Claudia T. Cariani; Piera Mondellini; Carla Calderone; Silvana Pilotti; Marco A. Pierotti; Giuseppe Della Porta

• Book ID: 102845425
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 651 KB
• Volume: 5
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870050307

✦ Synopsis

A combined cytogenetic and molecular analysis was performed on I I cases of papillary thyroid carcinoma. A simple karyotypic abnormality was detected in five tumors, whereas six had no apparent chromosome change. In four of five rearranged cases the presence of a specific chromosomal abnormality involving chromosome 10 (cases I and 2) and chromosome I (cases 3 and 4) was associated with the rearrangement of two protooncogenes: RET and NTRKl (formerly trk), respectively, with different donor genes. Moreover, the chromosomal localization of the involved genes and the type of chromosomal change observed suggested that RET and NTRK1 activation occurred by intrachromosomal rearrangements. The six cases with normal karyotype did not show RET or NTRKl activation. These findings suggest that a combined cytogenetic and molecular approach would be useful in understanding the pathogenesis of thyroid neoplasia. Genes Chrom Cancer 5.2 12-2 I8 ( 1 992).