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Cytogenetic heterogeneity and progression of esophageal squamous cell carcinoma

โœ Scribed by Hisanori Shiomi; Hiroyuki Sugihara; Sumihiro Kamitani; Tomoki Tokugawa; Yasuhiro Tsubosa; Katsuji Okada; Hiroki Tamura; Tohru Tani; Masashi Kodama; Takanori Hattori


Book ID
114135661
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
451 KB
Volume
147
Category
Article
ISSN
0165-4608

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p27 Kip1 , one of the cyclin-dependent kinase (CDK) inhibitors (CDKIs), blocks progression from G 1 to S phase by binding cyclin D1-CDK4 and/or cyclin E-CDK2 and inhibiting their activities. Reflecting the function of p27 as a CDKI in vitro, a reduced expression of protein p27 has recently been repo