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Cytogenetic effects of cyclophosphamide on mouse spermatogonia

✍ Scribed by R. Rathenberg

Publisher
Springer
Year
1975
Tongue
English
Weight
331 KB
Volume
29
Category
Article
ISSN
0340-6717

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✦ Synopsis

NMRI mice were treated with single doses of cyclophosphamide (Cytoxan) and spermatogonia were analysed for chromosome aberrations at various time intervals after treatment. The maxima of aberrations were found 24 hrs p.i. Chromatid type aberrations were observed exclusively. About half of the aberrations consisted of chromatid interchanges, 92% of which exchanging short arm fragments close to the centromeric region. The lack of meiotic multivalents in diakinesis-metaphase I after treatment of spermatogonia stem cells with cyclophosphamide in the study of Leonard and Linden (1972) is discussed.

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