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Cytogenetic and molecular mechanisms of resistance to imatinib

✍ Scribed by Andreas Hochhaus

Book ID
117832618
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
287 KB
Volume
40
Category
Article
ISSN
1532-8686

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## Abstract Chronic myelogenous leukemia (CML) is a disorder of hematopoietic stem cells that results from the Philadelphia chromosome (Ph) created through translocation of human chromosomes 9 and 22. The resulting Bcr‐Abl fusion protein has constitutively high tyrosine kinase activity that causes