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Cytochrome P450 Protocols Volume 320 || Spectrophotometric Analysis of Human CYP2E1-Catalyzed p-Nitrophenol Hydroxylation

✍ Scribed by Ian, Phillips R.; Elizabeth, Shephard A.


Book ID
120888773
Publisher
Humana Press
Year
2005
Weight
720 KB
Edition
2
Category
Article
ISBN-13
9781592599981

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Chlormethiazole is a sedative and anticonvulsive drug used in the treatment of alcohol withdrawal. Because it had been reported that chlormethiazole inhibits the alcohol-inducible cytochrome P450 2E1 in rat liver, we investigated the in vivo and in vitro effect of this drug on cytochrome P450 2E1 in