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Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors

✍ Scribed by Katalin Monostory; Eszter Hazai; László Vereczkey


Book ID
113517041
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
120 KB
Volume
147
Category
Article
ISSN
0009-2797

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Chlormethiazole is a sedative and anticonvulsive drug used in the treatment of alcohol withdrawal. Because it had been reported that chlormethiazole inhibits the alcohol-inducible cytochrome P450 2E1 in rat liver, we investigated the in vivo and in vitro effect of this drug on cytochrome P450 2E1 in