A fast and robust LC/MS-based cytochrome P450 (CYP) inhibition assay, using human liver microsomes, has been fully developed and validated for the major human liver CYPs. Probe substrates were phenacetin, diclofenac, S-mephenytoin, and dextromethorphan for CYP1A2, CYP2C9, CYP2C19, and CYP2D6, respec
โฆ LIBER โฆ
Cytochrome P450 2C24: expression, tissue distribution, high-throughput assay, and pharmacological inhibition
โ Scribed by Jun Yang; Melissa A. VanAlstine; James G. Phillips; Mark P. Wentland; Lindsay B. Hough
- Book ID
- 116243442
- Publisher
- Elsevier
- Year
- 2012
- Tongue
- English
- Weight
- 608 KB
- Volume
- 2
- Category
- Article
- ISSN
- 2211-3835
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