๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Cytochrome P450 2C24: expression, tissue distribution, high-throughput assay, and pharmacological inhibition

โœ Scribed by Jun Yang; Melissa A. VanAlstine; James G. Phillips; Mark P. Wentland; Lindsay B. Hough


Book ID
116243442
Publisher
Elsevier
Year
2012
Tongue
English
Weight
608 KB
Volume
2
Category
Article
ISSN
2211-3835

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


In vitro assessment of cytochrome P450 i
โœ Lin, Tong (author);Pan, Kristine (author);Mordenti, Joyce (author);Lin, Pan (aut ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons Inc. ๐ŸŒ English โš– 153 KB ๐Ÿ‘ 1 views

A fast and robust LC/MS-based cytochrome P450 (CYP) inhibition assay, using human liver microsomes, has been fully developed and validated for the major human liver CYPs. Probe substrates were phenacetin, diclofenac, S-mephenytoin, and dextromethorphan for CYP1A2, CYP2C9, CYP2C19, and CYP2D6, respec

Validation of higher-throughput high-per
โœ Inhou Chu; Leonard Favreau; Tony Soares; Chin-chung Lin; Amin A. Nomeir ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 166 KB ๐Ÿ‘ 2 views

In the early stage of drug discovery, thousands of new chemical entities (NCEs) may be screened before a single drug candidate can be identified for development. In order to accelerate the drug discovery process, we have developed higher-throughput enzyme assays to evaluate the inhibition of cytochr