Cyclosporin enhances diabetes induced by low-dose streptozotocin treatment in mice
β Scribed by C. Sestier; S. Odent-Pogu; M. Bonneville; C. Maurel; F. Lang; P. Sai
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 428 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0165-2478
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In mice, an experimental autoimmune diabetes can be induced by multiple injections with low doses of streptozotocin. Since different mouse strains show a varying susceptibility towards this treatment, we have examined whether the experimental autoimmune diabetes is under the genetic control of the m
Pancreatic islet inflammation and subsequent diabetes was induced by multiple low doses of streptozotocin in male C57 B1/6J mice. The development of hyperglycaemia was almost completely prevented by treating the animals with the cd-adrenoceptor antagonist prazosin (20mg.kg -1. day -1) as well as by