The pharmacokinetic parameters of cyclosporine (CsA) were determined in 23 kidney transplant recipients and 19 children with nephrotic syndrome, after intravenous and oral administration. The mean bioavailability was 39 %, blood clearance was 0.55 1 โข h -1 โข kg -1 and volume of distribution at stea
โฆ LIBER โฆ
Cyclosporin A in paediatric kidney transplantation
โ Scribed by G. Offner; P. F. Hoyer; J. Brodehl; R. Pichlmayr
- Publisher
- Springer
- Year
- 1987
- Tongue
- English
- Weight
- 586 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0931-041X
No coin nor oath required. For personal study only.
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## Abstract ## BACKGROUND Immunosuppressive agents may have an impact on ischemia/reperfusion injury. Both renal warm ischemia (RWI) and cyclosporine may contribute to chronic allograft dysfunction and delayed graft function (DGF). Interaction between cyclosporine and RWI in generating renal injur
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