Cyclopropane derivatives from the lithium aluminium hydride reduction of methoxyalkynols
✍ Scribed by J.W. Blunt; M.P. Hartshorn; M.H.G. Munro; Lee Tin Soong; R.W. Vannoort
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 110 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The factors influencing the ease of the lithium aluminium hydride reduction of various 1,2‐epoxycycloalkanes and 1,2‐epoxyalkanes are described and discussed.
Hydrides of group IVB elements have been prepared in high yield by heterogeneous reduction of the corresponding halo, alkoxy and amino derivatives using lithium aluminium hydride in non-polar solvents under ultrasonic irradiation.
Unsubstituted medium-ring 1,2-epoxycycloalkanes and certain vie-epoxyalkanes are reduced to the corresponding alcohols very slowly when LiAIH, alone is used as reducing agent. However, the combination of LiA1H4 and AICI,, in a 2:l molar ratio (with respect to 1 mol-equiv. of epoxide) used in refluxi