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Cyclophilin A is upregulated in small cell lung cancer and activates ERK1/2 signal

✍ Scribed by Huirong Yang; Jian Chen; Jingchun Yang; Shouyi Qiao; Shouyuan Zhao; Long Yu

Book ID
116295391
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
251 KB
Volume
361
Category
Article
ISSN
0006-291X

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## Abstract We have shown that the tobacco nitrosamine 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) is an agonist for β‐adrenergic receptors (β‐ARs) and increased DNA synthesis of human lung adenocarinoma cells with features of bronchiolar Clara cells by binding to these receptors. Using a