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Deregulation of DUSP activity in EGFR-mutant lung cancer cell lines contributes to sustained ERK1/2 signaling

✍ Scribed by Joel S. Britson; Frederick Barton; Justin M. Balko; Esther P. Black


Book ID
116299344
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
823 KB
Volume
390
Category
Article
ISSN
0006-291X

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✍ Marie-JosΓ©e Demers; Sonya Thibodeau; Dominique NoΓ«l; Naoya Fujita; Takashi Tsuru πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 527 KB

## Abstract Herein, we investigated the survival roles of Fak, Src, MEK/Erk, and PI3‐K/Akt‐1 in intestinal epithelial cancer cells (HCT116, HT29, and T84), in comparison to undifferentiated and differentiated intestinal epithelial cells (IECs). We report that: (1) cancer cells display striking anoi