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Mitoxantrone resistance in a small cell lung cancer cell line is associated with ABCA2 upregulation

โœ Scribed by Boonstra, R; Timmer-Bosscha, H; van Echten-Arends, J; van der Kolk, D M; van den Berg, A; de Jong, B; Tew, K D; Poppema, S; de Vries, E G E

Book ID
109998088
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
239 KB
Volume
90
Category
Article
ISSN
0007-0920

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Upregulation of bcl-2 is involved in the
Upregulation of bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines
โœ Ute A. Sartorius; Peter H. Krammer ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 325 KB

## Abstract Chemotherapeutic drugs eliminate cancer cells by induction of apoptosis. Resistance to chemotherapy is partly due to a decreased apoptosis rate. Here we investigated resistance to anticancer drugs in 9 small cell lung cancer (SCLC) cell lines. Apoptosis was induced by cisplatin, doxorub