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Cyclooxygenase-2 protein reduces tamoxifen and N-(4-hydroxyphenyl)retinamide inhibitory effects in breast cancer cells

✍ Scribed by Tari, Ana M; Simeone, Ann-Marie; Li, Yu-Jiang; Gutierrez-Puente, Yolanda; Lai, Syeling; Symmans, William F

Book ID
109885963
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
277 KB
Volume
85
Category
Article
ISSN
0023-6837

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## Abstract The synthetic retinoid __N__‐(4‐hydroxyphenyl)retinamide (4‐HPR) has been shown to induce apoptosis in various types of tumors, including prostate cancer. We sought to examine the key mechanisms affecting the resistance to 4‐HPR–induced apoptosis in three human prostate cancer cell line