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Cyclosporin A enhances the apoptotic effects of N-(4-hydroxyphenyl)retinamide in breast cancer cells

✍ Scribed by Soo-Jeong Lim; Ann-Marie Simeone; Chong-Kook Kim; Ana M. Tari

Publisher: John Wiley and Sons
Year: 2002
Tongue: French
Weight: 140 KB
Volume: 101
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.10596

No coin nor oath required. For personal study only.

✦ Synopsis

4HPR, an analogue of ATRA, effectively induces growth inhibition and apoptosis in breast cancer cell lines and animal models but is ineffective against advanced human breast tumors. Different compounds, including tamoxifen, are currently being tested to increase 4HPR efficacy in the clinic. Here, we report that cyclosporin A selectively increases the ability of 4HPR, but not ATRA, to induce growth inhibition and apoptosis in ER(+) and ER(-) breast cancer cell lines. Increased apoptosis by the 4HPR and cyclosporin A combination was correlated with increased production of the free radical nitric oxide. Thus, the 4HPR and cyclosporin A combination may potentially be a novel therapeutic modality against breast tumors.

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