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HER2/neu reduces the apoptotic effects of N-(4-hydroxyphenyl)retinamide (4-HPR) in breast cancer cells by decreasing nitric oxide production

โœ Scribed by Simeone, Ann-Marie; Broemeling, Lyle David; Rosenblum, Josh; Tari, Ana Maria

Book ID
110067874
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
210 KB
Volume
22
Category
Article
ISSN
0950-9232

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Cyclosporin A enhances the apoptotic effects of N-(4-hydroxyphenyl)retinamide in breast cancer cells
โœ Soo-Jeong Lim; Ann-Marie Simeone; Chong-Kook Kim; Ana M. Tari ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 140 KB

4HPR, an analogue of ATRA, effectively induces growth inhibition and apoptosis in breast cancer cell lines and animal models but is ineffective against advanced human breast tumors. Different compounds, including tamoxifen, are currently being tested to increase 4HPR efficacy in the clinic. Here, we