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Cyclooxygenase-2 increases hypoxia-inducible factor-1 and vascular endothelial growth factor to promote angiogenesis in gastric carcinoma

โœ Scribed by Shih-Pei Huang; Ming-Shiang Wu; Chia-Tung Shun; Hsiu-Po Wang; Chang-Yao Hsieh; Min-Liang Kuo; Jaw-Town Lin


Publisher
BioMed Central
Year
2005
Tongue
English
Weight
686 KB
Volume
12
Category
Article
ISSN
1021-7770

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## Abstract In oxygenated cells, hypoxiaโ€inducible factorโ€1 (HIFโ€1) ฮฑ subunits are rapidly degraded by a mechanism that involves ubiquitination by the von Hippelโ€“Lindau tumor suppressor E3 ligase complex using 2โ€oxoglutarate as a substrate. We examined the effect of 2โ€oxoglutarate on the production