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Cyclooxygenase-2 (Cox-2) independent inhibition of proliferation of colon cancer cells by 5-aminosalicylic acid (5-ASA)

✍ Scribed by C. Stolfi; D. Fina; R. Caruso; I. Peluso; V. Gioia; G.C. Naccari; S. Bellinvia; F. Andrei; C. Tosti; F. Pallone; G. Monteleone

Book ID
119631855
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
262 KB
Volume
38
Category
Article
ISSN
1590-8658

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High-level expression of cyclooxygenase (COX)-2 is reported in 80 -90% of colorectal adenocarcinomas. Selective inhibition of COX-2 was shown to reduce colorectal tumorigenesis in different models of carcinogenesis and to prevent metastasis in xenograft tumor models, as well as to suppress in vitro