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Cyclooxygenase-2 (COX-2) in Carcinogenesis and Selective COX-2 Inhibitors for Chemoprevention in Gastrointestinal Cancers

✍ Scribed by Takashi Fujimura; Tetsuo Ohta; Katsunobu Oyama; Tomoharu Miyashita; Kochi Miwa


Book ID
107574633
Publisher
Springer US
Year
2007
Tongue
English
Weight
162 KB
Volume
38
Category
Article
ISSN
1941-6628

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COX-2 and colon cancer: Potential target
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Evidence derived from several lines of investigation suggest that prostaglandins, metabolites of arachidonic acid, play an important role in colon cancer development. Elevated prostaglandin levels are found in colon cancers and their precursor lesions, adenomatous polyps. Agents such as aspirin and