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Cyclooxygenase-2 (Cox-2) expression and angiogenesis in glioblastoma

✍ Scribed by Onder Onguru; Mehmet Gamsizkan; Cuneyt Ulutin; Omer Gunhan


Book ID
108957973
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
250 KB
Volume
28
Category
Article
ISSN
0919-6544

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A series of methysulfonyl or sulfonamido substituted 4,5-diaryloxazole were prepared and evaluated for their ability to inhibit the inducible form of cyclooxygenase (COX-2) in vitro and in vivo. Several unique substitution patterns were identified that led to potent and selective inhibitors of COX-2