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Cycloheximide resistance in Chinese hamster cells I. Spontaneous mutagenesis

✍ Scribed by Hubert Pöche; Nina B. Varshaver; Erhard Geissler

Book ID
113190750
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
370 KB
Volume
27
Category
Article
ISSN
0027-5107

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Cycloheximide-resistance in Chinese hams
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✍ H. Pöche; K. H. Nierhaus; Sabine Zakrzewski 📂 Article 📅 1979 🏛 Springer 🌐 English ⚖ 463 KB

Cycloheximide(CHM)-resistant mutant Chinese hamster ovary (CHO) and human cells were induced with N-nitrosomethylurea (NMU) and ethyl methanesulfonate (EMS); the mutants were viable and showed unlimited growth in the presence of CHM (7 X 10(-7) M), whereas this concentration inhibits protein synthes