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Cycloheximide increases the thermostability of proteins in Chinese hamster ovary cells

✍ Scribed by Michael J. Borrelli; Yong J. Lee; Harold E. Frey; John P. Ofenstein; James R. Lepock

Book ID
115764737
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
466 KB
Volume
177
Category
Article
ISSN
0006-291X

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Cycloheximide-resistance in Chinese hams
Cycloheximide-resistance in Chinese hamster ovary cells and human fibroblast cells
✍ H. PΓΆche; K. H. Nierhaus; Sabine Zakrzewski πŸ“‚ Article πŸ“… 1979 πŸ› Springer 🌐 English βš– 463 KB

Cycloheximide(CHM)-resistant mutant Chinese hamster ovary (CHO) and human cells were induced with N-nitrosomethylurea (NMU) and ethyl methanesulfonate (EMS); the mutants were viable and showed unlimited growth in the presence of CHM (7 X 10(-7) M), whereas this concentration inhibits protein synthes