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Cyclodextrin-modified micellar electrokinetic chromatography for separation of norgestrel enantiomers

✍ Scribed by Liu, Yu ;Gu, Junling ;Fu, Ruonong

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
487 KB
Volume
20
Category
Article
ISSN
0935-6304

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✦ Synopsis

Abstract

A simple method for the separation of highly hydrophobic neutral enantiomers by cyclodextrin‐modified micellar electrokinetic chro‐matography (MEKC) is presented and strongly supported by experiments. The separation depends on the ratio between the concentrations of cyclodextrin (CD) and sodium dodecylsulfate (SDS) micelles and there is an optimum value of the ratio for the separation of the enantiomers of norgestrel and 4‐androstene‐3,17‐dione. At the optimum value of the ratio, obtained by adjusting the absolute concentrations of CD and SDS. The electrophoretic mobility difference between two enantiomers can be maintained nearly constant.

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