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Cyclodextrin chiral stationary phases for liquid chromatographic separations of drug stereoisomers

โœ Scribed by Alain Berthod; Heng Liang Jin; Thomas E. Beesley; Jo Dee Duncan; Daniel W. Armstrong

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
557 KB
Volume
8
Category
Article
ISSN
0731-7085

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โœฆ Synopsis

Many active drugs are racemic mixtures. Because the two enantiomers of a racemate often cause different pharmacological responses, the use of optically pure isomers is desirable and may be soon required. Cyclodextrin-bonded silica gel can be used as chiral stationary phase (CSP) in liquid chromatography. The enantiomers of 25 different racemic drugs were separated on such CSPs in the reversed-phase mode. The principal features of the cyclodextrin chiral recognition mechanism are recalled and some information on future trends for cyclodextrin CSPs is provided.

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