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Cycloaddition Reactions of Imines with 3-Thiosuccinic Anhydrides: Synthesis of the Tricyclic Core of Martinellic Acid
โ Scribed by Ng, Pui Yee; Masse, Craig E.; Shaw, Jared T.
- Book ID
- 127188572
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 750 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1523-7060
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The tricyclic triamine core 27 of martinellic acid (2) has been prepared stereospecifically in eight steps from 2-hydroxymethylaniline in 11% overall yield. The key steps are the addition of 2hydroxymethylaniline to vinylcyclopropane 14 to prepare cycloaddition precursor 19 in only two steps and an
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