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Cycloaddition Reactions of Imines with 3-Thiosuccinic Anhydrides: Synthesis of the Tricyclic Core of Martinellic Acid.

โœ Scribed by Pui Yee Ng; Craig E. Masse; Jared T. Shaw


Book ID
101997642
Publisher
John Wiley and Sons
Year
2007
Weight
26 KB
Volume
38
Category
Article
ISSN
0931-7597

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โœฆ Synopsis


Abstract

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Synthesis of the tricyclic triamine core
โœ Barry B. Snider; Yong Ahn; Bruce M. Foxman ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 247 KB

The tricyclic triamine core 27 of martinellic acid (2) has been prepared stereospecifically in eight steps from 2-hydroxymethylaniline in 11% overall yield. The key steps are the addition of 2hydroxymethylaniline to vinylcyclopropane 14 to prepare cycloaddition precursor 19 in only two steps and an