cyclo-SEM: A new carbonyl protecting group
β Scribed by Bruce H Lipshutz; Paul Mollard; Craig Lindsley; Virginia Chang
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 172 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
During the course of various synthetic projects under study in these Laboratories we have had occasion to devise and apply a number of new methods for the protection of hydroxyl' , carbony and la&one' functions. 4 We now wish to report some recent results on the protection of aldehydes and ketones
The protection of the 06-amide and N2-amino groups of guanosine with the (butylthio)carbonyl group is described. This group could be rapidly introduced in good yields and removed very easily under the conventional deprotective condition for the exo-amino acyl groups of other nucleoside bases.
## Abstract A new type of photolabile carbonylβprotecting group was utilized in releasing anticancer agents upon irradiation at 350 nm in an aqueous environment. (Β© WileyβVCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
The diethylisopropylsilyl (DEIPS) group which is a new protective group for alcohols has been first characterized. DEIPS group can be distinguished from t-butyldimethylsilyl, triethylsilyl, tetrahydropyranyl groups and 2-deoxy glycoside with high selectivity in removing under mild acidic condition,