✦ LIBER ✦

Cyclin D1 in mammary carcinoma

✍ Scribed by Barnes, Diana M.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 228 KB
Volume: 181
Category: Article
ISSN: 0022-3417
DOI: 10.1002/(sici)1096-9896(199703)181:3<267::aid-path783>3.0.co;2-x

No coin nor oath required. For personal study only.

✦ Synopsis

The control of the cell-cycle-associated protein cyclin D1 and its variable behaviour in normal and transformed cells is described and contrasted with its activity in vivo. The role of cyclin D1 as a prognostic and predictive marker is examined in clinical breast cancer. High levels of the protein are seen in well differentiated, oestrogen receptor positive tumours, which respond well to tamoxifen treatment for metastatic disease. 1997 by John Wiley & Sons, Ltd.

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