Cyclin-D1 expression in node-positive (N+) and node-negative (N−) infiltrating human mammary carcinomas

✍ Scribed by Paola Collecchi,; Anna Passoni; Marina Rocchetta; Elisa Gnesi; Editta Baldini; Generoso Bevilacqua

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: French
• Weight: 81 KB
• Volume: 84
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/(sici)1097-0215(19990420)84:2<139::aid-ijc8>3.0.co;2-y

✦ Synopsis

Cyclin-D1 (CD1) expression was analyzed in human mammary carcinomas by immunohistochemical (IHC) and flowcytometry (FCM) methods: 52.5% and 50% of cases were strong expressors of CD1 by IHC and FCM analysis respectively. The percentage of CD1-positive cells was especially high in node-negative (N ؊ ) estrogen-receptor-positive (ER ؉ ) tumors, probably as a consequence of CD1 induction by estrogens in steroid-responsive tissues. However, CD1 expression was not related to ER positivity in node-positive tumors (N ؉ ). An interesting relationship between CD1 expression and H 3 -thymidine labelling index (H 3 Td-LI) was also found: CD1 and H 3 Td-LI were unrelated in N ؊ tumors, while high CD1 expression was observed in N ؉ tumors with high DNA synthesis, as assessed by H 3 Td-LI. The combined measurement of DNA and CD1 showed that 27 specimens were aneuploid, 19 of them (19/27; 70%) strongly expressing CD1. Further studies are needed to clarify the role of CD1 in DNA abnormality of breast tumors. However, we cannot exclude that the CD1 may be differently de-regulated in the last phase of tumor progression, and that CD1 over-expression may contribute to the aneuploidy of mammary carcinomas.