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Cyclin D1 Genotype and Expression in Sporadic Hemangioblastomas

✍ Scribed by Johanna M. M. Gijtenbeek; Sandra H. E. Boots-Sprenger; Barbara Franke; Pieter Wesseling; Judith W. M. Jeuken


Publisher
Springer US
Year
2005
Tongue
English
Weight
289 KB
Volume
74
Category
Article
ISSN
0167-594X

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Cyclin-D1 over-expression represents one of several common alterations in the G 1 -S transition associated with malignancies. Conclusive evidences indicate that cyclin D1 is a proto-oncogene and the gene is amplified or rearranged in different tumour types. Since very little is known about aberratio