Cyclin A in cell cycle control and cancer
β Scribed by C. H. Yam; T. K. Fung; R. Y. C. Poon
- Book ID
- 105757536
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 94 KB
- Volume
- 59
- Category
- Article
- ISSN
- 1420-682X
No coin nor oath required. For personal study only.
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## Abstract In breast cancer, cyclins D1 and E and the cyclinβdependent kinase inhibitors p21 (Waf1/Cip1)and p27 (Kip1) are important in cellβcycle control and as potential oncogenes or tumor suppressor genes. They are regulated in breast cancer cells following mitogenic stimuli including activatio
The past several years have witnessed a dramatic accumulation of experimental and clinical evidence supporting the notion that the cell cycle machinery is commonly targeted on oncogenesis. While numerous cell cycle regulators qualify as proto-oncogenes or tumour suppressors and their aberrations may