𝔖 Bobbio Scriptorium
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Cyclin A in cell cycle control and cancer

✍ Scribed by C. H. Yam; T. K. Fung; R. Y. C. Poon


Book ID
105757536
Publisher
Springer
Year
2002
Tongue
English
Weight
94 KB
Volume
59
Category
Article
ISSN
1420-682X

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## Abstract In breast cancer, cyclins D1 and E and the cyclin‐dependent kinase inhibitors p21 (Waf1/Cip1)and p27 (Kip1) are important in cell‐cycle control and as potential oncogenes or tumor suppressor genes. They are regulated in breast cancer cells following mitogenic stimuli including activatio

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The past several years have witnessed a dramatic accumulation of experimental and clinical evidence supporting the notion that the cell cycle machinery is commonly targeted on oncogenesis. While numerous cell cycle regulators qualify as proto-oncogenes or tumour suppressors and their aberrations may