Cell cycle control and cancer
β Scribed by Hans Peter Wagner
- Book ID
- 105625673
- Publisher
- Springer-Verlag
- Year
- 1998
- Tongue
- English
- Weight
- 730 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0019-5456
No coin nor oath required. For personal study only.
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The past several years have witnessed a dramatic accumulation of experimental and clinical evidence supporting the notion that the cell cycle machinery is commonly targeted on oncogenesis. While numerous cell cycle regulators qualify as proto-oncogenes or tumour suppressors and their aberrations may
## Abstract In breast cancer, cyclins D1 and E and the cyclinβdependent kinase inhibitors p21 (Waf1/Cip1)and p27 (Kip1) are important in cellβcycle control and as potential oncogenes or tumor suppressor genes. They are regulated in breast cancer cells following mitogenic stimuli including activatio