Cyclin Dependent Kinases and Cell Cycle Control (Nobel Lecture)
β Scribed by Paul Nurse
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 267 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1439-4227
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Precise control of cell-cycle progression is believed to be critical for normal development, while oncogenesis may be a direct result of its disturbance. Cellcycle progression is regulated predominantly by a series of serine/threonine kinases, the cyclin-dependent kinases (CDKs). The activities of t
p27, cyclin D1, and retinoblastoma (Rb) protein have been demonstrated using immunohistochemistry in 189 cases of primary breast carcinoma with long-term follow-up. There was a statistically significant association between the expression of p27 and both cyclin D1 and the retinoblastoma gene product
In the search for new risk factors at the molecular and cellular levels, clinical data [lymph-node involvement (LN) and stage] were used and 104 squamous-cell lung carcinomas were analyzed by immuno-histochemistry for expression of cyclin D1, cyclin A, cdk2, cdk4, RB, and E2F1. The results of the un