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Low-dose genistein induces cyclin-dependent kinase inhibitors and G1 cell-cycle arrest in human prostate cancer cells

✍ Scribed by Jian-Cheng Shen; Russell D. Klein; Qingyi Wei; Yongli Guan; John H. Contois; Thomas T. Y. Wang; Shine Chang; Stephen D. Hursting

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 185 KB
Volume: 29
Category: Article
ISSN: 0899-1987
DOI: 10.1002/1098-2744(200010)29:2<92::aid-mc6>3.0.co;2-q

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## Background: Despite the beneficial effects of androgen ablation therapy in patients with prostate carcinoma, advancing prostate cancer usually becomes hormone-refractory. we attempted to establish a new prostate cancer therapy by controlling the malignancy of tumor cells through the induction of