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Cyclic RGD peptides interfere with binding of theHelicobacter pyloriprotein CagL to integrins αVβ3and α5β1

✍ Scribed by Conradi, Jens; Huber, Sylwia; Gaus, Katharina; Mertink, Felix; Royo Gracia, Soledad; Strijowski, Ulf; Backert, Steffen; Sewald, Norbert


Book ID
113052036
Publisher
Springer
Year
2011
Tongue
English
Weight
706 KB
Volume
43
Category
Article
ISSN
0939-4451

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A convenient access to αVβ3/αVβ5 integri
✍ Didier Boturyn; Pascal Dumy 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 105 KB

The cyclopeptide (-RGDfK-) is a potent and selective a V b 3 /a V b 5 integrin ligand. A methodology for the conjugation of cyclo(-RGDfK-) through the regioselective derivatisation of lysine side chains, either in solution or directly on the solid support, is described. This provides a rapid and fle