✦ LIBER ✦
A convenient access to αVβ3/αVβ5 integrin ligand conjugates: regioselective solid-phase functionalisation of an RGD based peptide
✍ Scribed by Didier Boturyn; Pascal Dumy
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 105 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The cyclopeptide (-RGDfK-) is a potent and selective a V b 3 /a V b 5 integrin ligand. A methodology for the conjugation of cyclo(-RGDfK-) through the regioselective derivatisation of lysine side chains, either in solution or directly on the solid support, is described. This provides a rapid and flexible chemical entry to conjugated integrin ligands bearing reporter groups for biological investigations or reactive chemical functions for the preparation of new vector systems.