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Solid-phase syntheses of constrained RGD scaffolds and their binding to the αvβ3 integrin receptor

✍ Scribed by Miriam Royo; Wim Van Den Nest; Montserrat del Fresno; Ariadna Frieden; Dror Yahalom; Michael Rosenblatt; Michael Chorev; Fernando Albericio

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
234 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

We report the solid-phase synthesis of two different families, containing either diketopiperazine or hydantoin structures, of rigidified RGD mimetics and their binding affinity to the a v b 3 receptor.

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